Inhibitory Effect of N,N-Didesmethylgrossularine-1 on Inflammatory Cytokine Production in Lipopolysaccharide-Stimulated RAW 264.7 Cells

Inhibitory Effect of N,N-Didesmethylgrossularine-1 on Inflammatory Cytokine Production in Lipopolysaccharide-Stimulated RAW 264.7 Cells

N,N-Didesmethylgrossularine-1 (DDMG-1), a compound with a rare α-carboline structure, was isolated from an Indonesian ascidian Polycarpa aurata as responsible for the observed inhibitory activity against TNF-α production in lipopolysaccharide-stimulated murine macrophage-like RAW264.7 cells. DDMG-1...

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Bibliographic Details
Main Authors: Remy E. P. Mangindaan, Michio Namikoshi, Hiroshi Handa, Yasuaki Kabe, Jong-Soo Lee, Satoshi Sakamoto, Yuta Sato, Taiko Oda
Format: Article
Language:English
Published: MDPI AG 2009-11-01
Series:Marine Drugs
Subjects:
LPS
RAW 264.7 cells
NF-κB
TNF-α
N,N-didesmethylgrossularine-1
natural product
Online Access:http://www.mdpi.com/1660-3397/7/4/589/

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http://www.mdpi.com/1660-3397/7/4/589/

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