Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV

Increases in antibiotic usage and antimicrobial resistance occurrence have caused a dramatic reduction in the effectiveness of many frontline antimicrobial treatments. Topoisomerase inhibitors including fluoroquinolones are broad-spectrum antibiotics used to treat a range of infections, which stabil...

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Bibliographic Details
Main Authors: Scott Grossman, Colin W. G. Fishwick, Martin J. McPhillie
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceuticals
Subjects:
topoisomerase
DNA gyrase
topo IV
antibiotic
allosteric
ATPase
Online Access:https://www.mdpi.com/1424-8247/16/2/261

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https://www.mdpi.com/1424-8247/16/2/261

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