Computational SNP Analysis and Molecular Simulation Revealed the Most Deleterious Missense Variants in the NBD1 Domain of Human ABCA1 Transporter

Computational SNP Analysis and Molecular Simulation Revealed the Most Deleterious Missense Variants in the NBD1 Domain of Human ABCA1 Transporter

The ATP-binding cassette transporter A1 (ABCA1) is a membrane-bound exporter protein involved in regulating serum HDL level by exporting cholesterol and phospholipids to load up in lipid-poor ApoA-I and ApoE, which allows the formation of nascent HDL. Mutations in the <i>ABCA1</i> gene,...

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Bibliographic Details
Main Authors: Raju Dash, Md. Chayan Ali, Md. Liton Rana, Yeasmin Akter Munni, Largess Barua, Israt Jahan, Mst. Fatema Haque, Md. Abdul Hannan, Il Soo Moon
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
ABCA1
NBD1
nsSNPs
polymorphism
molecular dynamics simulations
in silico
Online Access:https://www.mdpi.com/1422-0067/21/20/7606

Internet

https://www.mdpi.com/1422-0067/21/20/7606

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