DNA passes through cohesin’s hinge as well as its Smc3–kleisin interface

The ring model proposes that sister chromatid cohesion is mediated by co-entrapment of sister DNAs inside a single tripartite cohesin ring. The model explains how Scc1 cleavage triggers anaphase but has hitherto only been rigorously tested using small circular mini-chromosomes in yeast, where covale...

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Bibliographic Details
Main Authors: James E Collier, Kim A Nasmyth
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-09-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/80310