iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva

iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva

Abstract Background Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease caused by a gain-of-function mutation in ACVR1, which is a bone morphogenetic protein (BMP) type I receptor. Moreover, it causes progressive heterotopic ossification (HO) in connective tissues. Using FOP patien...

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Bibliographic Details
Main Authors: Pan Gao, Yoshiko Inada, Akitsu Hotta, Hidetoshi Sakurai, Makoto Ikeya
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Stem Cell Research & Therapy
Subjects:
Fibrodysplasia ossificans progressiva
Heterotopic ossification
Induced pluripotent stem cells
Mesenchymal stem/stromal cells
ACVR2B-Fc fusion protein
Online Access:https://doi.org/10.1186/s13287-024-03691-7

Internet

https://doi.org/10.1186/s13287-024-03691-7

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