CTNNB1 mutations, TERT polymorphism and CD8+ cell densities in resected hepatocellular carcinoma are associated with longer time to recurrence

CTNNB1 mutations, TERT polymorphism and CD8+ cell densities in resected hepatocellular carcinoma are associated with longer time to recurrence

Abstract Background Hepatocellular carcinoma (HCC) is a fatal disease characterized by early genetic alterations in telomerase reverse transcriptase promoter (TERTp) and β-catenin (CTNNB1) genes and immune cell activation in the tumor microenvironment. As a novel approach, we wanted to assess patien...

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Bibliographic Details
Main Authors: Filip Ambrozkiewicz, Andriy Trailin, Lenka Červenková, Radka Vaclavikova, Vojtech Hanicinec, Mohammad Al Obeed Allah, Richard Palek, Vladislav Třeška, Ondrej Daum, Zbyněk Tonar, Václav Liška, Kari Hemminki
Format: Article
Language:English
Published: BMC 2022-08-01
Series:BMC Cancer
Subjects:
β-Catenin
TERT promoter
CD8+ cells
rs2853669
Hepatocellular carcinoma
Online Access:https://doi.org/10.1186/s12885-022-09989-0

Internet

https://doi.org/10.1186/s12885-022-09989-0

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