Systematic Validation of RNF213 Coding Variants in Japanese Patients With Moyamoya Disease

Systematic Validation of RNF213 Coding Variants in Japanese Patients With Moyamoya Disease

Background A founder variant of RNF213, p.R4810K (c.14429G>A, rs112735431), was recently identified as a major genetic risk factor for moyamoya disease (MMD) in Japan. Although the association of p.R4810K was reported to be highly significant and reproducible, the disease susceptibility of other...

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Bibliographic Details
Main Authors: Yosuke Moteki, Hideaki Onda, Hidetoshi Kasuya, Taku Yoneyama, Yoshikazu Okada, Kengo Hirota, Maki Mukawa, Tadashi Nariai, Shohei Mitani, Hiroyuki Akagawa
Format: Article
Language:English
Published: Wiley 2015-05-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cerebrovascular disorders
epidemiology
genetics
risk factors
Online Access:https://doi.org/10.1161/JAHA.115.001862

Internet

https://doi.org/10.1161/JAHA.115.001862

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