Valproic acid as adjuvant treatment for convulsive status epilepticus: a randomised clinical trial

Valproic acid as adjuvant treatment for convulsive status epilepticus: a randomised clinical trial

Abstract Background Generalised convulsive status epilepticus (GCSE) is a medical emergency. Guidelines recommend a stepwise strategy of benzodiazepines followed by a second-line anti-seizure medicine (ASM). However, GCSE is uncontrolled in 20–40% patients and is associated with protracted hospitali...

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Main Authors: Tarek Sharshar, Raphaël Porcher, Pierre Asfar, Lamiae Grimaldi, Julien Jabot, Laurent Argaud, Christine Lebert, Pierre-Edouard Bollaert, Marie Line Harlay, Patrick Chillet, Eric Maury, Francois Santoli, Pascal Blanc, Romain Sonneville, Dinh Chuyen Vu, Benjamin Rohaut, Aurelien Mazeraud, Jean-Claude Alvarez, Vincent Navarro, Bernard Clair, Hervé Outin, the Valse investigators and for the Groupe d’Explorations Neurologiques en Reanimation (GENER)
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Critical Care
Subjects:
Generalised convulsive status epilepticus
Intensive care unit
Seizure
Valproic acid
Online Access:https://doi.org/10.1186/s13054-022-04292-7

Internet

https://doi.org/10.1186/s13054-022-04292-7

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