Repurposing Benzimidazoles against Causative Agents of Chromoblastomycosis: Albendazole Has Superior In Vitro Activity Than Mebendazole and Thiabendazole

Repurposing Benzimidazoles against Causative Agents of Chromoblastomycosis: Albendazole Has Superior In Vitro Activity Than Mebendazole and Thiabendazole

Chromoblastomycosis (CBM) is a neglected human implantation mycosis caused by several dematiaceous fungal species. Currently available therapy is usually associated with physical methods, especially surgery, and with high refractoriness. Therefore, drug discovery for CBM is essential. Drug repositio...

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Bibliographic Details
Main Authors: Rowena Alves Coelho, Maria Helena Galdino Figueiredo-Carvalho, Fernando Almeida-Silva, Vanessa Brito de Souza Rabello, Gabriela Rodrigues de Souza, Leandro Stefano Sangenito, Luna Sobrino Joffe, André Luis Souza dos Santos, Maria Cristina da Silva Lourenço, Marcio L. Rodrigues, Rodrigo Almeida-Paes
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Journal of Fungi
Subjects:
chromoblastomycosis
<i>Fonsecaea pedrosoi</i>
drug repositioning
benzimidazoles
albendazole
Online Access:https://www.mdpi.com/2309-608X/9/7/753

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https://www.mdpi.com/2309-608X/9/7/753

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