Generation of 17q21.31 duplication iPSC-derived neurons as a model for primary tauopathies

Generation of 17q21.31 duplication iPSC-derived neurons as a model for primary tauopathies

Tau proteins belong to the microtubule associated protein family and are mainly expressed in neurons. Tau accumulates in patients’ brain in several neurodegenerative diseases, including Fronto-temporal dementia and Alzheimer’s disease. Recently, we described a 17q21.31 duplication in patients presen...

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Bibliographic Details
Main Authors: Laetitia Miguel, Anne Rovelet-Lecrux, Pascal Chambon, Géraldine Joly-Helas, Stéphane Rousseau, David Wallon, Stéphane Epelbaum, Thierry Frébourg, Dominique Campion, Gaël Nicolas, Magalie Lecourtois
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Stem Cell Research
Subjects:
Tauopathies
iPSC-induced neurons
MAPT
17q21.31
Tau
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506122001118

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http://www.sciencedirect.com/science/article/pii/S1873506122001118

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