Bcl-xL overexpression decreases GILZ levels and inhibits glucocorticoid-induced activation of caspase-8 and caspase-3 in mouse thymocytes

Bcl-xL overexpression decreases GILZ levels and inhibits glucocorticoid-induced activation of caspase-8 and caspase-3 in mouse thymocytes

Glucocorticoids promote thymocyte apoptosis and modulate transcription of numerous regulators of thymic apoptosis. Among these, glucocorticoid-induced leucine zipper (GILZ) is strongly upregulated in the thymus. We have previously demonstrated that GILZ decreases Bcl-xL expression, activates caspase...

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Bibliographic Details
Main Authors: Isabella Muscari, Sabrina Adorisio, Anna Marina Liberati, Trinh Thi Thuy, Tran Van Sung, Lorenza Cannarile, Emira Ayroldi, Carlo Riccardi, Domenico V. Delfino
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Journal of Translational Autoimmunity
Subjects:
Bcl-xL
Glucocorticoids
Caspase-8
Caspase-3
GILZ
Thymocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S2589909020300022

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http://www.sciencedirect.com/science/article/pii/S2589909020300022

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