Transcriptomes of Injured Lamprey Axon Tips: Single-Cell RNA-Seq Suggests Differential Involvement of MAPK Signaling Pathways in Axon Retraction and Regeneration after Spinal Cord Injury

Transcriptomes of Injured Lamprey Axon Tips: Single-Cell RNA-Seq Suggests Differential Involvement of MAPK Signaling Pathways in Axon Retraction and Regeneration after Spinal Cord Injury

Axotomy in the CNS activates retrograde signals that can trigger regeneration or cell death. Whether these outcomes use different injury signals is not known. Local protein synthesis in axon tips plays an important role in axon retraction and regeneration. Microarray and RNA-seq studies on cultured...

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Bibliographic Details
Main Authors: Li-Qing Jin, Yan Zhou, Yue-Sheng Li, Guixin Zhang, Jianli Hu, Michael E. Selzer
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
spinal cord injury
single cell RNA-seq
axon regeneration
MAPK pathway
circadian rhythm
local protein synthesis
Online Access:https://www.mdpi.com/2073-4409/11/15/2320

Internet

https://www.mdpi.com/2073-4409/11/15/2320

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