Conditional ablation of heparan sulfate expression in stromal fibroblasts promotes tumor growth in vivo

Conditional ablation of heparan sulfate expression in stromal fibroblasts promotes tumor growth in vivo

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Heparan sulfate (HS) is a glycocalyx component present in the extracellular matrix and cell-surface HS proteoglycans (HSPGs). Although HSPGs are known to play functional roles in multiple aspects of tumor development and progression, the effect of HS expression in the tumor stroma on tumor growth in...

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Bibliographic Details
Main Authors: Ayumi Niwa, Toshiaki Taniguchi, Hiroyuki Tomita, Hideshi Okada, Takamasa Kinoshita, Chika Mizutani, Mikiko Matsuo, Yuko Imaizumi, Takahito Kuroda, Koki Ichihashi, Takaaki Sugiyama, Tomohiro Kanayama, Yu Yamaguchi, Shigeyuki Sugie, Nobuhisa Matsuhashi, Akira Hara
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942975/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9942975/?tool=EBI

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