Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1α signaling

Abstract Impaired locomotion has been extensively studied worldwide because those afflicted with it have a potential risk of becoming bedridden. Physical exercise at times can be an effective remedy for frailty, but exercise therapy cannot be applied in all clinical cases. Medication is safer than e...

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Bibliographic Details
Main Authors: Takehito Ono, Ryosuke Denda, Yuta Tsukahara, Takashi Nakamura, Kazuo Okamoto, Hiroshi Takayanagi, Tomoki Nakashima
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-022-00225-w