Network integration of thermal proteome profiling with multi-omics data decodes PARP inhibition

Network integration of thermal proteome profiling with multi-omics data decodes PARP inhibition

Abstract Complex disease phenotypes often span multiple molecular processes. Functional characterization of these processes can shed light on disease mechanisms and drug effects. Thermal Proteome Profiling (TPP) is a mass-spectrometry (MS) based technique assessing changes in thermal protein stabili...

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Bibliographic Details
Main Authors: Mira L Burtscher, Stephan Gade, Martin Garrido-Rodriguez, Anna Rutkowska, Thilo Werner, H Christian Eberl, Massimo Petretich, Natascha Knopf, Katharina Zirngibl, Paola Grandi, Giovanna Bergamini, Marcus Bantscheff, Maria Fälth-Savitski, Julio Saez-Rodriguez
Format: Article
Language:English
Published: Springer Nature 2024-03-01
Series:Molecular Systems Biology
Subjects:
Proteomics
Thermal Proteome Profiling
Biological Networks
Multi-omics
Online Access:https://doi.org/10.1038/s44320-024-00025-w

Internet

https://doi.org/10.1038/s44320-024-00025-w

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