An in vivo accelerated developmental myelination model for testing promyelinating therapeutics

An in vivo accelerated developmental myelination model for testing promyelinating therapeutics

Abstract Background Therapeutic agents stimulating the process of myelination could be beneficial for the treatment of demyelinating diseases, such as multiple sclerosis. The efficient translation of compounds promoting myelination in vitro to efficacy in vivo is inherently time-consuming and expens...

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Bibliographic Details
Main Authors: Karen Lariosa-Willingham, Dmitri Leonoudakis, Timo Bragge, Laura Tolppanen, Antti Nurmi, Megan Flanagan, Janelle Gibson, David Wilson, Jennifer Stratton, Kimmo K. Lehtimäki, Diana Miszczuk
Format: Article
Language:English
Published: BMC 2022-05-01
Series:BMC Neuroscience
Subjects:
Promyelinating
Diffusion tensor imaging
Fractional anisotropy
Thyroxine
Rat
MRI
Online Access:https://doi.org/10.1186/s12868-022-00714-y

Internet

https://doi.org/10.1186/s12868-022-00714-y

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