Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion

Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion

Malignant pleural effusion (MPE) is a life-threatening cancer-related disorder. Here, the authors show that KRAS-mutant tumor cells require IKKα, activated via host-provided IL-1β, to promote MPE development and that co-inhibition of both KRAS and IKKα ameliorates the development of MPE in mouse mod...

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Bibliographic Details
Main Authors: Antonia Marazioti, Ioannis Lilis, Malamati Vreka, Hara Apostolopoulou, Argyro Kalogeropoulou, Ioanna Giopanou, Georgia A. Giotopoulou, Anthi C. Krontira, Marianthi Iliopoulou, Nikolaos I. Kanellakis, Theodora Agalioti, Anastasios D. Giannou, Celestial Jones-Paris, Yoichiro Iwakura, Dimitrios Kardamakis, Timothy S. Blackwell, Stavros Taraviras, Magda Spella, Georgios T. Stathopoulos
Format: Article
Language:English
Published: Nature Portfolio 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03051-z

Internet

https://doi.org/10.1038/s41467-018-03051-z

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