Multiparametric grading of glaucoma severity by histopathology can enable post-mortem substratification of disease state

Multiparametric grading of glaucoma severity by histopathology can enable post-mortem substratification of disease state

Abstract Neurodegeneration in glaucoma patients is clinically identified through longitudinal assessment of structure–function changes, including intraocular pressure, cup-to-disc ratios from fundus images, and optical coherence tomography imaging of the retinal nerve fiber layer. Use of human post-...

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Bibliographic Details
Main Authors: Chuanxi Xiang, VijayKrishna Raghunathan, Yubin Qiu, Manisha Mehta, John T. Demirs, Cynthia L. Grosskreutz, Christopher W. Wilson, Ganesh Prasanna
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Acta Neuropathologica Communications
Subjects:
Glaucoma
Retinal nerve fiber layer
Pathology grading
Neurodegeneration
Histology
Multivariate analysis
Online Access:https://doi.org/10.1186/s40478-024-01880-2

Internet

https://doi.org/10.1186/s40478-024-01880-2

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