Nanoparticles of Thiolated Xanthan Gum for the Oral Delivery of Miconazole Nitrate: In Vitro and In Vivo Evaluation

Nanoparticles of Thiolated Xanthan Gum for the Oral Delivery of Miconazole Nitrate: In Vitro and In Vivo Evaluation

The objective of this research was to develop a mucoadhesive delivery system that improves permeation for the administration of poorly absorbed oral medications. Thiolation of xanthan gum (XGM) was carried out by esterification with mercaptobutyric acid. Fourier-transformed infrared spectroscopy was...

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Bibliographic Details
Main Authors: Nader I. Namazi, Hamad Alrbyawi, Abdulkareem Ali Alanezi, Afaf F Almuqati, Anwar Shams, Hany S. M. Ali
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Pharmaceutics
Subjects:
xanthan gum
thiolation
nanoparticles
antifungal activity
pharmacokinetics
Online Access:https://www.mdpi.com/1999-4923/16/2/225

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https://www.mdpi.com/1999-4923/16/2/225

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