The CXCL16-CXCR6 axis in glioblastoma modulates T-cell activity in a spatiotemporal context

The CXCL16-CXCR6 axis in glioblastoma modulates T-cell activity in a spatiotemporal context

IntroductionGlioblastoma multiforme (GBM) pathobiology is characterized by its significant induction of immunosuppression within the tumor microenvironment, predominantly mediated by immunosuppressive tumor-associated myeloid cells (TAMCs). Myeloid cells play a pivotal role in shaping the GBM microe...

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Main Authors: Tzu-Yi Chia, Leah K. Billingham, Lauren Boland, Joshua L. Katz, Victor A. Arrieta, Jack Shireman, Aurora-Lopez Rosas, Susan L. DeLay, Kaylee Zillinger, Yuheng Geng, Jeandre Kruger, Caylee Silvers, Hanxiang Wang, Gustavo Ignacio Vazquez Cervantes, David Hou, Si Wang, Hanxiao Wan, Adam Sonabend, Peng Zhang, Catalina Lee-Chang, Jason Miska
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
glioblastoma
CXCL16
CXCR6
immunotherapy
myeloid cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1331287/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1331287/full

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