MicroRNA-200a regulates Grb2 and suppresses differentiation of mouse embryonic stem cells into endoderm and mesoderm.

MicroRNA-200a regulates Grb2 and suppresses differentiation of mouse embryonic stem cells into endoderm and mesoderm.

The mechanisms by which microRNAs (miRNAs) affect cell fate decisions remain poorly understood. Herein, we report that miR-200a can suppress the differentiation of mouse embryonic stem (ES) cells into endoderm and mesoderm. Interestingly, miR-200a directly targets growth factor receptor-bound protei...

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Bibliographic Details
Main Authors: Yang Liu, Qidong Liu, Wenwen Jia, Jie Chen, Jianmin Wang, Dan Ye, Xudong Guo, Wen Chen, Guoping Li, Guiying Wang, Anmei Deng, Jiuhong Kang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3715486?pdf=render

Internet

http://europepmc.org/articles/PMC3715486?pdf=render

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