Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19

Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19

Summary: Clotting Factor V (FV) is primarily synthesized in the liver and when cleaved by thrombin forms pro-coagulant Factor Va (FVa). Using whole blood RNAseq and scRNAseq of peripheral blood mononuclear cells, we find that FV mRNA is expressed in leukocytes, and identify neutrophils, monocytes, a...

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Main Authors: Jun Wang, Prasanti Kotagiri, Paul A. Lyons, Rafia S. Al-Lamki, Federica Mescia, Laura Bergamaschi, Lorinda Turner, Michael D. Morgan, Fernando J. Calero-Nieto, Karsten Bach, Nicole Mende, Nicola K. Wilson, Emily R. Watts, Patrick H. Maxwell, Patrick F. Chinnery, Nathalie Kingston, Sofia Papadia, Kathleen E. Stirrups, Neil Walker, Ravindra K. Gupta, David K. Menon, Kieren Allinson, Sarah J. Aitken, Mark Toshner, Michael P. Weekes, James A. Nathan, Sarah R. Walmsley, Willem H. Ouwehand, Mary Kasanicki, Berthold Göttgens, John C. Marioni, Kenneth G.C. Smith, Jordan S. Pober, John R. Bradley
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:iScience
Subjects:
Immunology
Microbiology
Omics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222002413

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http://www.sciencedirect.com/science/article/pii/S2589004222002413

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