Calling the amino acid sequence of a protein/peptide from the nanospectrum produced by a sub-nanometer diameter pore

Abstract The blockade current that develops when a protein translocates across a thin membrane through a sub-nanometer diameter pore informs with extreme sensitivity on the sequence of amino acids that constitute the protein. The current blockade signals measured during the translocation are called...

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Bibliographic Details
Main Authors: Xiaowen Liu, Zhuxin Dong, Gregory Timp
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-22305-x