A Tryptophan Metabolite of the Microbiota Improves Neovascularization in Diabetic Limb Ischemia

A Tryptophan Metabolite of the Microbiota Improves Neovascularization in Diabetic Limb Ischemia

Diabetes mellitus (DM) is accompanied by a series of macrovascular and microvascular injuries. Critical limb ischemia is the most severe manifestation of peripheral artery disease (PAD) caused by DM and is almost incurable. Therapeutic modulation of angiogenesis holds promise for the prevention of l...

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Bibliographic Details
Main Authors: Xiurui Ma, Jinjing Yang, Guanrui Yang, Lei Li, Xiaojun Hao, Guoqin Wang, Jian An, Fei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
diabetes mellitus
limb ischemia
indole-3-aldehyde
mitochondrial dysfunction
oxidative stress
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.910323/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.910323/full

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