Superoxide-Mediated Upregulation of MMP9 Participates in BMPR2 Destabilization and Pulmonary Hypertension Development

Superoxide-Mediated Upregulation of MMP9 Participates in BMPR2 Destabilization and Pulmonary Hypertension Development

Background and Aims: we previously reported in studies on organoid-cultured bovine pulmonary arteries that pulmonary hypertension (PH) conditions of exposure to hypoxia or endothelin-1 caused a loss of a cartilage oligomeric matrix protein (COMP) stabilization of bone morphogenetic protein receptor-...

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Bibliographic Details
Main Authors: Norah Alruwaili, Sharath Kandhi, Ghezal Froogh, Melissa R. Kelly, Dong Sun, Michael S. Wolin
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Antioxidants
Subjects:
MMP9
BMPR2
pulmonary hypertension
superoxide
oxidative stress
extracellular matrix
Online Access:https://www.mdpi.com/2076-3921/12/11/1961

Internet

https://www.mdpi.com/2076-3921/12/11/1961

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