Fine-grained age-matching improves atrophy-based detection of mild cognitive impairment more than amyloid-negative reference subjects

Fine-grained age-matching improves atrophy-based detection of mild cognitive impairment more than amyloid-negative reference subjects

Introduction: In clinical practice, differentiating between age-related gray matter (GM) atrophy and neurodegeneration-related atrophy at early disease stages, such as mild cognitive impairment (MCI), remains challenging. We hypothesized that fined-grained adjustment for age effects and using amyloi...

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Bibliographic Details
Main Authors: Nils Richter, Stefanie Brand, Nils Nellessen, Julian Dronse, Hannes Gramespacher, Maximilian H.T. Schmieschek, Gereon R. Fink, Juraj Kukolja, Oezguer A. Onur
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:NeuroImage: Clinical
Subjects:
Gray matter
Alzheimer’s disease
MRI
Z-statistics
ADNI
Voxel-based-morphometry
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158223001997

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http://www.sciencedirect.com/science/article/pii/S2213158223001997

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