Pramipexole Upregulates Dopamine Receptor D2 and D3 Expression in Rat Striatum
Randomized clinical trials have shown that pramipexole has an antidepressant effect in patients with Parkinson’s disease. We investigated the comparative efficacy of pramipexole toward dopamine receptor D2 and D3 expression in rat brain. Groups of rats were treated subacutely with pramipexole (1 mg/...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319304529 |
| _version_ | 1818483530385063936 |
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| author | Naohito Tokunaga Mohammed Emamussalehin Choudhury Noriko Nishikawa Masahiro Nagai Tomoaki Tujii Hirotaka Iwaki Mika Kaneta Masahiro Nomoto |
| author_facet | Naohito Tokunaga Mohammed Emamussalehin Choudhury Noriko Nishikawa Masahiro Nagai Tomoaki Tujii Hirotaka Iwaki Mika Kaneta Masahiro Nomoto |
| author_sort | Naohito Tokunaga |
| collection | DOAJ |
| description | Randomized clinical trials have shown that pramipexole has an antidepressant effect in patients with Parkinson’s disease. We investigated the comparative efficacy of pramipexole toward dopamine receptor D2 and D3 expression in rat brain. Groups of rats were treated subacutely with pramipexole (1 mg/kg), imipramine (10 mg/kg), or bromocriptine (5 mg/kg), with appropriate controls. Using real-time RT-PCR and immunoblotting, dopamine receptor D2 and D3 expression was up-regulated in the striatum following pramipexole treatment, while imipramine and bromocriptine had no significant effects. These findings support that pramipexole exerts additional therapeutic benefits such as decreasing depression by increasing dopamine receptor D3 expression in the striatum. Keywords:: dopamine receptor, Parkinson’s disease, pramipexole |
| first_indexed | 2024-12-10T15:43:05Z |
| format | Article |
| id | doaj.art-6a68db04e5bf408d8bbecd46b3090c62 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-10T15:43:05Z |
| publishDate | 2012-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-6a68db04e5bf408d8bbecd46b3090c622022-12-22T01:43:04ZengElsevierJournal of Pharmacological Sciences1347-86132012-01-011202133137Pramipexole Upregulates Dopamine Receptor D2 and D3 Expression in Rat StriatumNaohito Tokunaga0Mohammed Emamussalehin Choudhury1Noriko Nishikawa2Masahiro Nagai3Tomoaki Tujii4Hirotaka Iwaki5Mika Kaneta6Masahiro Nomoto7Department of Therapeutic Medicine (Clinical Pharmacology and Neurology), Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan; Present address: Department of Bioscience, Ehime University, Integrated Center for Science, Toon, Ehime 791-0295, JapanDepartment of Therapeutic Medicine (Clinical Pharmacology and Neurology), Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, JapanDepartment of Therapeutic Medicine (Clinical Pharmacology and Neurology), Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, JapanDepartment of Therapeutic Medicine (Clinical Pharmacology and Neurology), Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, JapanDepartment of Therapeutic Medicine (Clinical Pharmacology and Neurology), Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, JapanDepartment of Therapeutic Medicine (Clinical Pharmacology and Neurology), Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, JapanDepartment of Therapeutic Medicine (Clinical Pharmacology and Neurology), Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, JapanDepartment of Therapeutic Medicine (Clinical Pharmacology and Neurology), Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan; Corresponding author. nomoto@m.ehime-u.ac.jpRandomized clinical trials have shown that pramipexole has an antidepressant effect in patients with Parkinson’s disease. We investigated the comparative efficacy of pramipexole toward dopamine receptor D2 and D3 expression in rat brain. Groups of rats were treated subacutely with pramipexole (1 mg/kg), imipramine (10 mg/kg), or bromocriptine (5 mg/kg), with appropriate controls. Using real-time RT-PCR and immunoblotting, dopamine receptor D2 and D3 expression was up-regulated in the striatum following pramipexole treatment, while imipramine and bromocriptine had no significant effects. These findings support that pramipexole exerts additional therapeutic benefits such as decreasing depression by increasing dopamine receptor D3 expression in the striatum. Keywords:: dopamine receptor, Parkinson’s disease, pramipexolehttp://www.sciencedirect.com/science/article/pii/S1347861319304529 |
| spellingShingle | Naohito Tokunaga Mohammed Emamussalehin Choudhury Noriko Nishikawa Masahiro Nagai Tomoaki Tujii Hirotaka Iwaki Mika Kaneta Masahiro Nomoto Pramipexole Upregulates Dopamine Receptor D2 and D3 Expression in Rat Striatum Journal of Pharmacological Sciences |
| title | Pramipexole Upregulates Dopamine Receptor D2 and D3 Expression in Rat Striatum |
| title_full | Pramipexole Upregulates Dopamine Receptor D2 and D3 Expression in Rat Striatum |
| title_fullStr | Pramipexole Upregulates Dopamine Receptor D2 and D3 Expression in Rat Striatum |
| title_full_unstemmed | Pramipexole Upregulates Dopamine Receptor D2 and D3 Expression in Rat Striatum |
| title_short | Pramipexole Upregulates Dopamine Receptor D2 and D3 Expression in Rat Striatum |
| title_sort | pramipexole upregulates dopamine receptor d2 and d3 expression in rat striatum |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319304529 |
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