Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice

Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice

Objective: Insulin-like peptide 5 (INSL5) signalling, through its cognate receptor relaxin/insulin-like family peptide receptor 4 (RXFP4), has been reported to be orexigenic, and the high fat diet (HFD) preference observed in wildtype mice is altered in Rxfp4 knock-out mice. In this study, we used a...

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Bibliographic Details
Main Authors: Jo E. Lewis, Orla RM. Woodward, Danaé Nuzzaci, Christopher A. Smith, Alice E. Adriaenssens, Lawrence Billing, Cheryl Brighton, Benjamin U. Phillips, John A. Tadross, Sarah J. Kinston, Ernesto Ciabatti, Berthold Göttgens, Marco Tripodi, David Hornigold, David Baker, Fiona M. Gribble, Frank Reimann
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Metabolism
Subjects:
RXFP4
Insl5
CNS
VMH
Food intake
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822001739

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http://www.sciencedirect.com/science/article/pii/S2212877822001739

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