CYP2J2-derived epoxyeicosatrienoic acids protect against doxorubicin-induced cardiotoxicity by reducing oxidative stress and apoptosis via activation of the AMPK pathway

CYP2J2-derived epoxyeicosatrienoic acids protect against doxorubicin-induced cardiotoxicity by reducing oxidative stress and apoptosis via activation of the AMPK pathway

Objective: Despite the widespread use of doxorubicin (DOX) in chemotherapy, it can cause cardiotoxicity, which severely limits its potential clinical use. CYP2J2-derived epoxyeicosatrienoic acids (EETs) exert cardioprotective effects by maintaining cardiac homeostasis. The roles and latent mechanism...

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Bibliographic Details
Main Authors: Chuanmeng Zhu, Yang Bai, Jie Qiu, Guangzhi Chen, Xiaomei Guo, Renfan Xu
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Heliyon
Subjects:
Cardiotoxicity
Doxorubicin
EETs
Apoptosis
Oxidative stress
AMPK
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023107341

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http://www.sciencedirect.com/science/article/pii/S2405844023107341

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