Posttranslational Acylations of the Rat Brain Transketolase Discriminate the Enzyme Responses to Inhibitors of ThDP-Dependent Enzymes or Thiamine Transport

Posttranslational Acylations of the Rat Brain Transketolase Discriminate the Enzyme Responses to Inhibitors of ThDP-Dependent Enzymes or Thiamine Transport

Transketolase (TKT) is an essential thiamine diphosphate (ThDP)-dependent enzyme of the non-oxidative branch of the pentose phosphate pathway, with the glucose-6P flux through the pathway regulated in various medically important conditions. Here, we characterize the brain TKT regulation by acylation...

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Bibliographic Details
Main Authors: Vasily A. Aleshin, Thilo Kaehne, Maria V. Maslova, Anastasia V. Graf, Victoria I. Bunik
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
transketolase
malonylation
acetylation
sirtuin 5
oxythiamine
metformin
Online Access:https://www.mdpi.com/1422-0067/25/2/917

Internet

https://www.mdpi.com/1422-0067/25/2/917

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