Differential modulation of mutant CALR and JAK2 V617F-driven oncogenesis by HLA genotype in myeloproliferative neoplasms

Differential modulation of mutant CALR and JAK2 V617F-driven oncogenesis by HLA genotype in myeloproliferative neoplasms

It has been demonstrated previously that human leukocyte antigen class I (HLA-I) and class II (HLA-II) alleles may modulate JAK2 V617F and CALR mutation (CALRmut)-associated oncogenesis in myeloproliferative neoplasms (MPNs). However, the role of immunogenetic factors in MPNs remains underexplored....

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Bibliographic Details
Main Authors: Velizar Shivarov, Gergana Tsvetkova, Ilina Micheva, Evgueniy Hadjiev, Jasmina Petrova, Anela Ivanova, Galia Madjarova, Milena Ivanova
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Immunology
Subjects:
immunoediting
HLA
MPN
mutation
CALR
JAK2 V617F
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1427810/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1427810/full

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