Activation of the Extracytoplasmic Function σ Factor σV in Clostridioides difficile Requires Regulated Intramembrane Proteolysis of the Anti-σ Factor RsiV

Activation of the Extracytoplasmic Function σ Factor σV in Clostridioides difficile Requires Regulated Intramembrane Proteolysis of the Anti-σ Factor RsiV

ABSTRACT Clostridioides (Clostridium) difficile is one of the leading causes of nosocomial diarrhea. Lysozyme is a common host defense against many pathogenic bacteria. C. difficile exhibits high levels of lysozyme resistance, which is due in part to the extracytoplasmic functioning (ECF) σ factor,...

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Bibliographic Details
Main Authors: Anthony G. Pannullo, Craig D. Ellermeier
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:mSphere
Subjects:
σ factors
cell envelope
stress response
signal transduction
gene expression
sigma factors
Online Access:https://journals.asm.org/doi/10.1128/msphere.00092-22

Internet

https://journals.asm.org/doi/10.1128/msphere.00092-22

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