Novel Donepezil–Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer’s Disease

Novel Donepezil–Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer’s Disease

Alzheimer’s disease (AD) is one of the most devastating neurodegenerative disorders, characterized by multiple pathological features. Therefore, multi-target drug discovery has been one of the most active fields searching for new effective anti-AD therapies. Herein, a series of hybrid compounds are...

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Bibliographic Details
Main Authors: Fausto Queda, Sonia Calò, Karolina Gwizdala, João D. Magalhães, Sandra M. Cardoso, Sílvia Chaves, Luca Piemontese, M. Amélia Santos
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
arylsulfonamide
donepezil
anti-neurodegeneratives
Alzheimer´s disease
AChE inhibitors
A<i>β</i> aggregation
Online Access:https://www.mdpi.com/1420-3049/26/6/1658

Internet

https://www.mdpi.com/1420-3049/26/6/1658

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