Improving the Biological Properties of Thrombin-Binding Aptamer by Incorporation of 8-Bromo-2′-Deoxyguanosine and 2′-Substituted RNA Analogues

Improving the Biological Properties of Thrombin-Binding Aptamer by Incorporation of 8-Bromo-2′-Deoxyguanosine and 2′-Substituted RNA Analogues

Thrombin-binding aptamer (TBA) is one of the best-known G-quadruplex (G4)-forming aptamers. By adopting its peculiar chair-like G4 structure, TBA can efficiently bind to thrombin, thus producing an anticoagulant effect. The major limit to its therapeutic application is represented by its poor therma...

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Bibliographic Details
Main Authors: Antonella Virgilio, Daniela Benigno, Carla Aliberti, Valentina Vellecco, Mariarosaria Bucci, Veronica Esposito, Aldo Galeone
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
G-quadruplex
thrombin binding aptamer
8-bromo-2′-deoxyguanosine
RNA analogues
anticoagulant activity
Online Access:https://www.mdpi.com/1422-0067/24/21/15529

Internet

https://www.mdpi.com/1422-0067/24/21/15529

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