Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms

Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms

Abstract Background Acquired imatinib (IM) resistance is frequently characterized by Bcr-Abl mutations that affect IM binding and kinase inhibition in patients with chronic myelogenous leukemia (CML). Bcr-Abl-T315I mutation is the predominant mechanism of the acquired resistance to IM. Therefore, it...

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Bibliographic Details
Main Authors: Xiaoying Lan, Chong Zhao, Xin Chen, Peiquan Zhang, Dan Zang, Jinjie Wu, Jinghong Chen, Huidan Long, Li Yang, Hongbiao Huang, Bing Z. Carter, Xuejun Wang, Xianping Shi, Jinbao Liu
Format: Article
Language:English
Published: BMC 2016-11-01
Series:Journal of Hematology & Oncology
Subjects:
Nickel pyrithione
Apoptosis
Chronic myelogenous leukemia
Imatinib resistance
Bcr-Abl
Online Access:http://link.springer.com/article/10.1186/s13045-016-0359-x

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http://link.springer.com/article/10.1186/s13045-016-0359-x

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