Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity

Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity

Abstract Background Bariatric surgery remains the most effective therapy for adiposity reduction and remission of type 2 diabetes. Although different bariatric procedures associate with pronounced shifts in the gut microbiota, their functional role in the regulation of energetic and metabolic benefi...

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Bibliographic Details
Main Authors: Julia Münzker, Nadine Haase, Andreas Till, Robert Sucher, Sven-Bastiaan Haange, Linda Nemetschke, Thorsten Gnad, Elisabeth Jäger, Jiesi Chen, Sjaak J. Riede, Rima Chakaroun, Lucas Massier, Peter Kovacs, Mario Ost, Ulrike Rolle-Kampczyk, Nico Jehmlich, Juliane Weiner, John T. Heiker, Nora Klöting, Gudrun Seeger, Markus Morawski, Verena Keitel, Alexander Pfeifer, Martin von Bergen, Joerg Heeren, Ute Krügel, Wiebke K. Fenske
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Microbiome
Subjects:
Gastric bypass
Gut microbiota
FXR
TGR5
Bile acids
Taurine metabolism
Online Access:https://doi.org/10.1186/s40168-022-01264-5

Internet

https://doi.org/10.1186/s40168-022-01264-5

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