Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer

Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer

Abstract Epithelial‐mesenchymal transition (EMT) is a reversible transcriptional program invoked by cancer cells to drive cancer progression. Transcription factor ZEB1 is a master regulator of EMT, driving disease recurrence in poor‐outcome triple negative breast cancers (TNBCs). Here, this work sil...

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Bibliographic Details
Main Authors: Charlene Waryah, Joseph Cursons, Momeneh Foroutan, Christian Pflueger, Edina Wang, Ramyar Molania, Eleanor Woodward, Anabel Sorolla, Christopher Wallis, Colette Moses, Irina Glas, Leandro Magalhães, Erik W. Thompson, Liam G. Fearnley, Christine L. Chaffer, Melissa Davis, Anthony T. Papenfuss, Andrew Redfern, Ryan Lister, Manel Esteller, Pilar Blancafort
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Advanced Science
Subjects:
cancer epigenetics
CRISPR/dCas9 repression
epithelial‐mesenchymal transition
triple negative breast cancer
ZEB1
Online Access:https://doi.org/10.1002/advs.202301802

Internet

https://doi.org/10.1002/advs.202301802

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