IL-1β augments TGF-β inducing epithelial-mesenchymal transition of epithelial cells and associates with poor pulmonary function improvement in neutrophilic asthmatics

IL-1β augments TGF-β inducing epithelial-mesenchymal transition of epithelial cells and associates with poor pulmonary function improvement in neutrophilic asthmatics

Abstract Background Neutrophilic asthmatics (NA) have less response to inhaled corticosteroids. We aimed to find out the predictor of treatment response in NA. Methods Asthmatics (n = 115) and healthy controls (n = 28) underwent clinical assessment during 6-month follow-up with standardized therapy....

Full description

Bibliographic Details
Main Authors: Shengding Zhang, Yu Fan, Lu Qin, Xiaoyu Fang, Cong Zhang, Junqing Yue, Wenxue Bai, Gang Wang, Zhihong Chen, Harld Renz, Chrysanthi Skevaki, Xiansheng Liu, Min Xie
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Respiratory Research
Subjects:
Asthma
Epithelial-mesenchymal transition
IL-1β
Pulmonary function
TGF-β1
Online Access:https://doi.org/10.1186/s12931-021-01808-7

Internet

https://doi.org/10.1186/s12931-021-01808-7

Similar Items