Transition from Preinvasive Carcinoma In Situ to Seminoma Is Accompanied by a Reduction of Connexin 43 Expression in Sertoli Cells and Germ Cells

Transition from Preinvasive Carcinoma In Situ to Seminoma Is Accompanied by a Reduction of Connexin 43 Expression in Sertoli Cells and Germ Cells

Carcinoma in situ (CIS) represents the preinvasive stage of human germ cell tumors, but the mechanism leading to pubertal proliferation and invasive malignancy remains unknown. Among testicular gap functional proteins, connexin 43 (Cx43) represents the predominant Cx, and, previously, an inverse cor...

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Bibliographic Details
Main Authors: Ralph Brehm, Christina Ruttinger, Petra Fischer, Isabella Gashaw, Elke Winterhager, Sabine Kliesch, Rainer M. Bohle, Klaus Steger, Martin Bergmann
Format: Article
Language:English
Published: Elsevier 2006-06-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Carcinoma in situ
seminoma
downregulation
connexin 43
gene expression
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558606800321

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http://www.sciencedirect.com/science/article/pii/S1476558606800321

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