Valine-mediated borane reduction of ketones

Acetophenone, 3,3-dimethyl-2-butanone, 3-methyl-2-butanone, and 2-pentanone were reduced with (S)-valine-mediated borane in very good yields (86-91 %) giving predominantly alcohols of the (R)-configuration (80, 64, 55 and 36 % ee, respectively).

Bibliographic Details
Main Authors: J. N. MILOVANOVIC, B. M. MOJSILOVIC, M. D. JOKSOVIC, S. K. KONSTANTINOVIC, A. V. TEODOROVIC
Format: Article
Language:English
Published: Serbian Chemical Society 2000-08-01
Series:Journal of the Serbian Chemical Society
Subjects:
Online Access:http://www.shd.org.yu/HtDocs/SHD/Vol65/No8-Pdf/jscs8-02.pdf