Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD+/SIRT6 axis

Temporal dynamics of base excision/single-strand break repair protein complex assembly/disassembly are modulated by the PARP/NAD+/SIRT6 axis

Summary: Assembly and disassembly of DNA repair protein complexes at DNA damage sites are essential for maintaining genomic integrity. Investigating factors coordinating assembly of the base excision repair (BER) proteins DNA polymerase β (Polβ) and XRCC1 to DNA lesion sites identifies a role for Po...

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Bibliographic Details
Main Authors: Christopher A. Koczor, Kate M. Saville, Joel F. Andrews, Jennifer Clark, Qingming Fang, Jianfeng Li, Rasha Q. Al-Rahahleh, Md Ibrahim, Steven McClellan, Mikhail V. Makarov, Marie E. Migaud, Robert W. Sobol
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Cell Reports
Subjects:
DNA polymerase β
XRCC1
poly(ADP-ribose)
PAR
NAD+
NRH
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721013905

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721013905

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