Vagotomy accelerates the onset of symptoms during early disease progression and worsens joint-level pathogenesis in a male rat model of chronic knee osteoarthritis

Vagotomy accelerates the onset of symptoms during early disease progression and worsens joint-level pathogenesis in a male rat model of chronic knee osteoarthritis

Objective: Low vagal tone is common in osteoarthritis (OA) comorbidities and results in greater peripheral inflammation. Characterizing vagal tone's role in OA pathogenesis may offer insights into OA's influences beyond the articular joint. We hypothesized that low vagal tone would acceler...

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Bibliographic Details
Main Authors: Carlos J. Cruz, Taylor D. Yeater, Jacob L. Griffith, Kyle D. Allen
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Osteoarthritis and Cartilage Open
Subjects:
Osteoarthritis
Autonomic nervous system
Vagotomy
Brain-joint axis
Rat model
Online Access:http://www.sciencedirect.com/science/article/pii/S2665913124000347

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http://www.sciencedirect.com/science/article/pii/S2665913124000347

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