Formononetin ameliorates cisplatin-induced hair cell death via activation of the PI3K/AKT-Nrf2 signaling pathway

Formononetin ameliorates cisplatin-induced hair cell death via activation of the PI3K/AKT-Nrf2 signaling pathway

Cisplatin (CDDP) stands as a highly effective chemotherapeutic agent; however, its ototoxicity remains a perplexing challenge in the field. Formononetin (FMNT), a potent flavonoid isolated from Astragalus membranaceus, displays a diverse range of promising pharmacological activities, encompassing an...

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Bibliographic Details
Main Authors: Yimeng Li, Jingfang Wu, Huiqian Yu, Xiaoling Lu, Yusu Ni
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Heliyon
Subjects:
Formononetin
Reactive oxygen species (ROS)
Ototoxicity
Cisplatin
Hair cell
Phosphatidylinositol-3-kinase (PI3K)/ serine/threonine kinase 1 (AKT)
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023109583

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http://www.sciencedirect.com/science/article/pii/S2405844023109583

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