AAV-mediated delivery of osteoblast/osteoclast-regulating miRNAs for osteoporosis therapy

AAV-mediated delivery of osteoblast/osteoclast-regulating miRNAs for osteoporosis therapy

Osteoporosis occurs due to a dysregulation in bone remodeling, a process requiring both bone-forming osteoblasts and bone-resorbing osteoclasts. Current leading osteoporosis therapies suppress osteoclast-mediated bone resorption but show limited therapeutic effects because osteoblast-mediated bone f...

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Bibliographic Details
Main Authors: Aijaz Ahmad John, Jun Xie, Yeon-Suk Yang, Jung-Min Kim, Chujiao Lin, Hong Ma, Guangping Gao, Jae-Hyuck Shim
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
rAAV
bone
osteoblast
osteoclast
osteoporosis
miR-214-3p
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253122001779

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http://www.sciencedirect.com/science/article/pii/S2162253122001779

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