A Deletion Encompassing the Furin Cleavage Site in the Spike Encoding Gene Does Not Alter SARS-CoV-2 Replication in Lung Tissues of Mink and Neutralization by Convalescent Human Serum Samples

A Deletion Encompassing the Furin Cleavage Site in the Spike Encoding Gene Does Not Alter SARS-CoV-2 Replication in Lung Tissues of Mink and Neutralization by Convalescent Human Serum Samples

SARS-CoV-2 has been shown to lose the furin polybasic cleavage site (FCS) following adaptation on cell culture. Deletion occurring in this region, which may include also the FCS flanking regions, seem not to affect virus replication in vitro; however, a chimeric SARS-CoV-2 virus without the sole FCS...

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Bibliographic Details
Main Authors: Fabrizia Valleriani, Lucija Jurisic, Chiara Di Pancrazio, Roberta Irelli, Eugenia Ciarrocchi, Michele Martino, Antonio Cocco, Elisabetta Di Felice, Maria Loredana Colaianni, Nicola Decaro, Barbara Bonfini, Alessio Lorusso, Giovanni Di Teodoro
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Pathogens
Subjects:
D614G
respiratory ex vivo organ culture
minks
SARS-CoV-2
furin cleavage site deletion
viral replication
Online Access:https://www.mdpi.com/2076-0817/11/10/1152

Internet

https://www.mdpi.com/2076-0817/11/10/1152

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