Identification of a Functional Non-coding Variant in the GABAA Receptor α2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research

Identification of a Functional Non-coding Variant in the GABAA Receptor α2 Subunit of the C57BL/6J Mouse Reference Genome: Major Implications for Neuroscience Research

GABA type-A (GABA-A) receptors containing the α2 subunit (GABRA2) are expressed in most brain regions and are critical in modulating inhibitory synaptic function. Genetic variation at the GABRA2 locus has been implicated in epilepsy, affective and psychiatric disorders, alcoholism and drug abuse. Ga...

Full description

Bibliographic Details
Main Authors: Megan K. Mulligan, Timothy Abreo, Sarah M. Neuner, Cory Parks, Christine E. Watkins, M. Trevor Houseal, Thomas M. Shapaker, Michael Hook, Haiyan Tan, Xusheng Wang, Jesse Ingels, Junmin Peng, Lu Lu, Catherine C. Kaczorowski, Camron D. Bryant, Gregg E. Homanics, Robert W. Williams
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Genetics
Subjects:
GABRA2
C57BL/6J
GABA-A receptor
neuroscience
genetics
CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00188/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00188/full

Similar Items