Compensatory cross-talk between autophagy and glycolysis regulates senescence and stemness in heterogeneous glioblastoma tumor subpopulations

Compensatory cross-talk between autophagy and glycolysis regulates senescence and stemness in heterogeneous glioblastoma tumor subpopulations

Abstract Despite tremendous research efforts, successful targeting of aberrant tumor metabolism in clinical practice has remained elusive. Tumor heterogeneity and plasticity may play a role in the clinical failure of metabolism-targeting interventions for treating cancer patients. Moreover, compensa...

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Dades bibliogràfiques
Autors principals: Emma Martell, Helgi Kuzmychova, Harshal Senthil, Esha Kaul, Chirayu R. Chokshi, Chitra Venugopal, Christopher M. Anderson, Sheila K. Singh, Tanveer Sharif
Format: Article
Idioma:English
Publicat: BMC 2023-07-01
Col·lecció:Acta Neuropathologica Communications
Matèries:
Glioblastoma
Tumor heterogeneity
Cancer stem cell-like cells
Metabolism
Glycolysis
Autophagy
Accés en línia:https://doi.org/10.1186/s40478-023-01604-y

Internet

https://doi.org/10.1186/s40478-023-01604-y

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