Compensatory cross-talk between autophagy and glycolysis regulates senescence and stemness in heterogeneous glioblastoma tumor subpopulations

Compensatory cross-talk between autophagy and glycolysis regulates senescence and stemness in heterogeneous glioblastoma tumor subpopulations

Abstract Despite tremendous research efforts, successful targeting of aberrant tumor metabolism in clinical practice has remained elusive. Tumor heterogeneity and plasticity may play a role in the clinical failure of metabolism-targeting interventions for treating cancer patients. Moreover, compensa...

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Bibliographic Details
Main Authors: Emma Martell, Helgi Kuzmychova, Harshal Senthil, Esha Kaul, Chirayu R. Chokshi, Chitra Venugopal, Christopher M. Anderson, Sheila K. Singh, Tanveer Sharif
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Acta Neuropathologica Communications
Subjects:
Glioblastoma
Tumor heterogeneity
Cancer stem cell-like cells
Metabolism
Glycolysis
Autophagy
Online Access:https://doi.org/10.1186/s40478-023-01604-y

Internet

https://doi.org/10.1186/s40478-023-01604-y

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