Compensatory cross-talk between autophagy and glycolysis regulates senescence and stemness in heterogeneous glioblastoma tumor subpopulations

Compensatory cross-talk between autophagy and glycolysis regulates senescence and stemness in heterogeneous glioblastoma tumor subpopulations

Abstract Despite tremendous research efforts, successful targeting of aberrant tumor metabolism in clinical practice has remained elusive. Tumor heterogeneity and plasticity may play a role in the clinical failure of metabolism-targeting interventions for treating cancer patients. Moreover, compensa...

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Bibliografski detalji
Glavni autori: Emma Martell, Helgi Kuzmychova, Harshal Senthil, Esha Kaul, Chirayu R. Chokshi, Chitra Venugopal, Christopher M. Anderson, Sheila K. Singh, Tanveer Sharif
Format: Članak
Jezik:English
Izdano: BMC 2023-07-01
Serija:Acta Neuropathologica Communications
Teme:
Glioblastoma
Tumor heterogeneity
Cancer stem cell-like cells
Metabolism
Glycolysis
Autophagy
Online pristup:https://doi.org/10.1186/s40478-023-01604-y

Internet

https://doi.org/10.1186/s40478-023-01604-y

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