Compensatory cross-talk between autophagy and glycolysis regulates senescence and stemness in heterogeneous glioblastoma tumor subpopulations

Compensatory cross-talk between autophagy and glycolysis regulates senescence and stemness in heterogeneous glioblastoma tumor subpopulations

Abstract Despite tremendous research efforts, successful targeting of aberrant tumor metabolism in clinical practice has remained elusive. Tumor heterogeneity and plasticity may play a role in the clinical failure of metabolism-targeting interventions for treating cancer patients. Moreover, compensa...

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Chi tiết về thư mục
Những tác giả chính: Emma Martell, Helgi Kuzmychova, Harshal Senthil, Esha Kaul, Chirayu R. Chokshi, Chitra Venugopal, Christopher M. Anderson, Sheila K. Singh, Tanveer Sharif
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: BMC 2023-07-01
Loạt:Acta Neuropathologica Communications
Những chủ đề:
Glioblastoma
Tumor heterogeneity
Cancer stem cell-like cells
Metabolism
Glycolysis
Autophagy
Truy cập trực tuyến:https://doi.org/10.1186/s40478-023-01604-y

Internet

https://doi.org/10.1186/s40478-023-01604-y

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